Anti-Prothrombin Screen is an ELISA test system for the quantitative measurement of IgG, IgM and IgA class autoantibodies against prothrombin in human serum or plasma. This product is intended for professional in vitro diagnostic use only. Antiphospholipid syndrome (APS, Hughes Syndrome) is a systemic autoimmune disease that causes thromboses, recurrent miscarriage or stillbirths, and stroke. Clinical symptoms are accompanied by specific autoantibodies in the blood, which bind to phospholipids like cardiolipin, or phospholipid-binding proteins like beta-2-glycoprotein I. Autoantibodies against proteins of the coagulation cascade, e.g. prothrombin or annexin V may also be found in patients with APS with otherwise negative phospholipid antibody results. In primary APS autoantibodies against phospholipids appear independently, while in secondary APS phospholipid antibodies are detected in conjunction with other autoimmune diseases, such as lupus erythematosus, rheumatoid arthritis, or Sjögren’s syndrome.
ORGENTEC Diagnostika
діагностична компанія із м. Майнц, Німеччина, орієнтована на автоматизацію лабораторних досліджень у сферах аутоімунності та інфекційних захворювань.
Ензимні імуноферментні аналізи (ІФА), імуноблоти та імунофлуоресцентні аналізи виробляються в Німеччині, Майнц
