ANCAcombi is an ELISA test system for the qualitative measurement of anti-neutrophil cytoplasmic antibodies (ANCA) directed against PR3, MPO, BPI, Elastase, Cathepsin G, Lysozyme and Lactoferrin in human serum or plasma. This product is intended for professional in vitro diagnostic use only.
INTENDED PURPOSE
Anti-neutrophil cytoplasmic antibodies (ANCA) against proteinase 3 (PR3) or myeloperoxidase (MPO) are diagnostic markers for ANCA-associated vasculitides. PR3 is the landmark antigen in granulomatosis with polyangiitis (GPA, formerly: Wegener's granulomatosis). MPO differentiates microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA). ANCA against lactoferrin, elastase, cathepsin-G, lysozyme, and bactericidal permeability-increasing protein (BPI) may occur in inflammatory rheumatic diseases and in chronic inflammatory intestinal conditions. The test supports the differential diagnosis of these diseases when used in combination with other laboratory and clinical findings.
